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NCS TOX PROJECT
Predictive database to determine the toxicological profile of Natural Complex Substances - Plants extracts
Launch of NCS TOX 1.2016-2017, the first phase of a global research project on the toxicology of botanicals.
Within 13 months of the kick-off meeting, players will have at their disposal a preliminary evaluation of risk of molecules contained in plants, based on existing data, text mining, in silico models and expertise.
This stage will focus on 3 following endpoints: genotoxicity, systemic toxicity and sensitisation.
Aiming on the long-term to provide a "Predictive database to determine the toxicological profile of Natural Complex Substances - Plants extracts", this is a Project of major importance for all stakeholders involved in the manufacture and in the use of plants and plant extracts, and especially for cosmetic and nutraceutical industries.
The innovative feature of this project lies on the fact that toxicological profiles of NCSs could be obtained thanks to safety data and information on their constituents made available in a predictive database.
A response to specific business factors
- A strongly competitive global marketplace where constant innovation is a key for competitivity and represents the main driver for development,
- Consumers' enthusiasm for natural products and a high expectation for their safety,
- A twofold deadlock to deal with the ban on animal testing and the lack of adequate validated key alternative methods enabling to demonstrate the products' safety,
- A European Regulation - 1223/2009 - which introduces a safety report of the finished product based on the knowledge of the toxicological profile of its ingredients,
- Natural Complex Substances are covered by the REACH Regulation but are most often exempted, either by nature or for quantitative purposes.
| A tool to assist users - botanical raw materials suppliers and their customers of the cosmetic industry - to update or carry out the toxicological profile of botanical extracts and set up the safety report as defined in Annex 1 to the European Cosmetic Regulation which stipulates that the safety of the finished product goes through the safety of ingredients. |
The first phase, launched on September 16, 2016, will last 13 months.
An innovative approach... |
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Benefits
+ Safety aspects can be taken into account as early as the early development stage
+ Preserve the capacity of innovation of the supply chain from the richness of the plant world
+ Savings on toxicological tests’ budgets
+ Improvement of the consumer’s safety.
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Partners of the "NCS TOX 1.2016-2017" Project:
| Consortium Members |
Country |
| Associations |
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| UNITIS |
France |
| the Botanical alliance |
France |
| Active Members |
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| ALBAN MULLER INTERNATIONAL |
France |
| CHANEL |
France |
| GREENTECH |
France |
| ID BIO |
France |
| IES LABO |
France |
| LETICC |
France |
| LUCAS MEYER COSMETICS |
France |
| LVMH RECHERCHE |
France |
| PIERRE FABRE DERMO-COSMETIQUE |
France |
| PILEJE |
France |
| PROVITAL S.A. |
Spain |
| RTD Performers |
|
| ISTITUTO MARIO NEGRI | Italy |
| GREENPHARMA | France |
| University of MANCHESTER |
United Kingdom |
| University of PARIS-DESCARTES |
France |
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NCS TOX Project - Press review
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What is UNITIS?
A professional European organization uniting companies involved in the field of cosmetic ingredients...
>> More detailsWhat's interest in joigning UNITIS?
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