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NCS TOX PROJECT

Predictive database to determine the toxicological profile of Natural Complex Substances - Plants extracts

A driver of growth for the natural cosmetic supply chain


Launch of NCS TOX 1.2016-2017, the first phase of a global research project on the toxicology of botanicals.

Within 13 months of the kick-off meeting, players will have at their disposal a preliminary evaluation of risk of molecules contained in plants, based on existing data, text mining, in silico models and expertise.

This stage will focus on 3 following endpoints: genotoxicity, systemic toxicity and sensitisation.

Aiming on the long-term to provide a "Predictive database to determine the toxicological profile of Natural Complex Substances - Plants extracts", this is a Project of major importance for all stakeholders involved in the manufacture and in the use of plants and plant extracts, and especially for cosmetic and nutraceutical industries.

The innovative feature of this project lies on the fact that toxicological profiles of NCSs could be obtained thanks to safety data and information on their constituents made available in a predictive database.




A response to specific business factors


  • A strongly competitive global marketplace where constant innovation is a key for competitivity and represents the main driver for development,
  • Consumers' enthusiasm for natural products and a high expectation for their safety,
  • A twofold deadlock to deal with the ban on animal testing and the lack of adequate validated key alternative methods enabling to demonstrate the products' safety,
  • A European Regulation - 1223/2009 - which introduces a safety report of the finished product based on the knowledge of the toxicological profile of its ingredients,
  • Natural Complex Substances are covered by the REACH Regulation but are most often exempted, either by nature or for quantitative purposes.

 
 
A tool to assist users - botanical raw materials suppliers and their customers of the cosmetic industry - to update or carry out the toxicological profile of botanical extracts and set up the safety report as defined in Annex 1 to the European Cosmetic Regulation which stipulates that the safety of the finished product goes through the safety of ingredients.
 
 

The UNITIS NCS TOX Project aims to provide a solution to the ambivalent scientific and regulatory context which acts as constraint to innovation, and to contribute to the development of a chain of excellence, world-renowned for its know-how.
The first phase, launched on September 16, 2016, will last 13 months.
 
 
 

 An innovative approach...





  • Which is based on knowledge of the constituents of plants
  • Which promotes the existing data through a preliminary work about census and collection in literature and industry
  • Which implements new analytical methods
  • Which uses new methods and approaches recognized by the European authorities such as TTC and predicive in silico models (QSARs)
  • Which unables to have an essential and unequelled level of knowledge in the field of the Natural Complex Substances chemistry and toxicology.

 
Benefits
 
+ Safety aspects can be taken into account as early as the early development stage
 
+ Preserve the capacity of innovation of the supply chain from the richness of the plant world
 
+ Savings on toxicological tests’ budgets
 
+ Improvement of the consumer’s safety.





Partners of the "NCS TOX 1.2016-2017" Project:


 Consortium Members
 Country
Associations
UNITIS
France
the Botanical alliance
France
Active Members
ALBAN MULLER INTERNATIONAL
France
CHANEL
France
GREENTECH
France
ID BIO
France
IES LABO
France
LETICC
France
LUCAS MEYER COSMETICS
France
LVMH RECHERCHE
France
PIERRE FABRE DERMO-COSMETIQUE
France
PILEJE
France
PROVITAL S.A.
Spain
RTD Performers
ISTITUTO MARIO NEGRI Italy
GREENPHARMA France
University of MANCHESTER
United Kingdom
University of PARIS-DESCARTES
France


NCS TOX Project - Press review
 

Last update : 15/12/17

What is UNITIS?

A professional European organization uniting companies involved in the field of cosmetic ingredients...

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What's interest in joigning UNITIS?

The answer can be done through a few words explaining what UNITIS brings to its members...

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the Botanical alliance

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